STOCHASTIC MODEL OF IN-VIVO X4 EMERGENCE DURING HIV INFECTION: IMPLICATIONS FOR THE CCR5 INHIBITOR MARAVIROC.



Statistical Power and Performance of Strategies to Analyze Composites of Survival and Duration of Ventilation in Clinical Trials

BACKGROUND:.Patients with acute hypoxemic respiratory failure are at high risk of death and prolonged time on the ventilator.Interventions often aim to reduce both mortality and time on the ventilator.Many methods have been proposed for analyzing these Dice endpoints as a single composite outcome (days alive and free of ventilation), but it is uncl

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Starvation-induced cell fusion and heterokaryosis frequently escape imperfect allorecognition systems in an asexual fungal pathogen

Abstract Background Asexual fungi include important pathogens of plants and other organisms, and their effective management requires understanding of their evolutionary dynamics.Genetic recombination is critical for adaptability and could be achieved via heterokaryosis — the co-existence of genetically different nuclei in a cell resulting from

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